Doxycycline Prophylaxis for Skin and Soft Tissue Infections in Naval Special Warfare Trainees, United States.

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dc.contributor.authorSpiro, Jeffrey
dc.contributor.authorWisniewski, Piotr
dc.contributor.authorSchwartz, Julia
dc.contributor.authorSmith, Alfred G
dc.contributor.authorBurger, Sara
dc.contributor.authorTilley, Drake H
dc.contributor.authorMaves, Ryan C
dc.date.accessioned2024-03-21T22:12:43Z
dc.date.available2024-03-21T22:12:43Z
dc.date.issued2024-01-01
dc.description.abstractIn 2015, several severe cases of skin and soft tissue infection (SSTI) among US Naval Special Warfare trainees prompted the introduction of doxycycline prophylaxis during the highest-risk portion of training, Hell Week. We performed a retrospective analysis of the effect of this intervention on SSTI incidence and resulting hospital admissions during 2013-2020. In total, 3,371 trainees underwent Hell Week training during the study period; 284 SSTIs were diagnosed overall, 29 of which led to hospitalization. After doxycycline prophylaxis was introduced, admission rates for SSTI decreased from 1.37 to 0.64 admissions/100 trainees (p = 0.036). Overall SSTI rates remained stable at 7.42 to 8.86 SSTIs/100 trainees (p = 0.185). Hospitalization rates per diagnosed SSTI decreased from 18.4% to 7.2% (p = 0.009). Average length of hospitalization decreased from 9.01 days to 4.33 days (p = 0.034). Doxycycline prophylaxis was associated with decreased frequency and severity of hospitalization for SSTIs among this population.
dc.identifier.other38146981
dc.identifier.urihttps://hdl.handle.net/10673/2453
dc.language.isoen
dc.relation.ispartofseriesReport number; 22-55
dc.relation.ispartofseriesDepartment number; OID-44
dc.subjectSSTI
dc.subjectUnited States
dc.subjectbacteria
dc.subjectdoxycycline
dc.subjectmilitary
dc.subjectprophylaxis
dc.subjectsaltwater exposure
dc.subjectskin and soft tissue infection
dc.titleDoxycycline Prophylaxis for Skin and Soft Tissue Infections in Naval Special Warfare Trainees, United States.
dc.typeArticle

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